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Showing 1 to 12 of 9224 entries
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Molecular recognition of gangliosides and their potential for cancer immunotherapies.

Frontiers in immunology

Krengel U, Bousquet PA.
PMID: 25101077
Front Immunol. 2014 Jul 21;5:325. doi: 10.3389/fimmu.2014.00325. eCollection 2014.

Gangliosides are sialic-acid-containing glycosphingolipids expressed on all vertebrate cells. They are primarily positioned in the plasma membrane with the ceramide part anchored in the membrane and the glycan part exposed on the surface of the cell. These lipids have...

Pattern recognition receptors and DNA repair: starting to put a jigsaw puzzle together.

Frontiers in immunology

Kutikhin AG, Yuzhalin AE, Tsitko EA, Brusina EB.
PMID: 25101085
Front Immunol. 2014 Jul 23;5:343. doi: 10.3389/fimmu.2014.00343. eCollection 2014.

No abstract available.

Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions.

Frontiers in immunology

Basner-Tschakarjan E, Mingozzi F.
PMID: 25101090
Front Immunol. 2014 Jul 23;5:350. doi: 10.3389/fimmu.2014.00350. eCollection 2014.

Adeno-associated virus (AAV) vectors are one of the most efficient in vivo gene delivery platforms. Over the past decade, clinical trials of AAV vector-mediated gene transfer led to some of the most exciting results in the field of gene...

The role of Peyer's patches in synchronizing gut IgA responses.

Frontiers in immunology

Lycke NY, Bemark M.
PMID: 23181060
Front Immunol. 2012 Nov 07;3:329. doi: 10.3389/fimmu.2012.00329. eCollection 2012.

Because Peyer's patches (PP) are the main inductive sites for gut IgA responses we have focused this review on what we know about the function of PP germinal centers (GC). The vast majority of IgA gene sequences in the...

Toll-like receptor 9 in breast cancer.

Frontiers in immunology

Sandholm J, Selander KS.
PMID: 25101078
Front Immunol. 2014 Jul 22;5:330. doi: 10.3389/fimmu.2014.00330. eCollection 2014.

Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune...

Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome.

Frontiers in immunology

O'Connell AE, Volpi S, Dobbs K, Fiorini C, Tsitsikov E, de Boer H, Barlan IB, Despotovic JM, Espinosa-Rosales FJ, Hanson IC, Kanariou MG, Martínez-Beckerat R, Mayorga-Sirera A, Mejia-Carvajal C, Radwan N, Weiss AR, Pai SY, Lee YN, Notarangelo LD.
PMID: 25101082
Front Immunol. 2014 Jul 18;5:340. doi: 10.3389/fimmu.2014.00340. eCollection 2014.

The Wiskott-Aldrich syndrome (WAS) is due to mutations of the WAS gene encoding for the cytoskeletal WAS protein, leading to abnormal downstream signaling from the T cell and B cell antigen receptors (TCR and BCR). We hypothesized that the...

TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease.

Frontiers in immunology

Mifsud EJ, Tan AC, Jackson DC.
PMID: 24624130
Front Immunol. 2014 Mar 03;5:79. doi: 10.3389/fimmu.2014.00079. eCollection 2014.

Immunotherapies that can either activate or suppress innate immune responses are being investigated as treatments against infectious diseases and the pathology they can cause. The objective of these therapies is to elicit protective immune responses thereby limiting the harm...

Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors.

Frontiers in immunology

Olmo IG, Carvalho TG, Costa VV, Alves-Silva J, Ferrari CZ, Izidoro-Toledo TC, da Silva JF, Teixeira AL, Souza DG, Marques JT, Teixeira MM, Vieira LB, Ribeiro FM.
PMID: 28878777
Front Immunol. 2017 Aug 23;8:1016. doi: 10.3389/fimmu.2017.01016. eCollection 2017.

Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants born from infected mothers. ZIKV exhibits high neurotropism and promotes neuroinflammation and neuronal cell death. We have recently demonstrated...

Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells.

Frontiers in immunology

Laffont S, Blanquart E, Guéry JC.
PMID: 28912783
Front Immunol. 2017 Aug 31;8:1069. doi: 10.3389/fimmu.2017.01069. eCollection 2017.

Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in...

Comparison of the Protective Efficacy of Neutralizing Epitopes of 2009 Pandemic H1N1 Influenza Hemagglutinin.

Frontiers in immunology

Peng B, Peng N, Zhang Y, Zhang F, Li X, Chang H, Fang F, Wang F, Lu F, Chen Z.
PMID: 28912784
Front Immunol. 2017 Aug 31;8:1070. doi: 10.3389/fimmu.2017.01070. eCollection 2017.

The 2009 H1N1 influenza (Pdm09) pandemic has been referred to as the first influenza pandemic of the twenty-first century. There is a marked difference in antigenicity between the pandemic H1N1 virus and past seasonal H1N1 viruses, which allowed the...

Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling Specificity.

Frontiers in immunology

Mukherjee A, Roy S, Saha B, Mukherjee D.
PMID: 26925059
Front Immunol. 2016 Feb 17;7:45. doi: 10.3389/fimmu.2016.00045. eCollection 2016.

No abstract available.

Integration of Immune Cell Populations, mRNA-Seq, and CpG Methylation to Better Predict Humoral Immunity to Influenza Vaccination: Dependence of mRNA-Seq/CpG Methylation on Immune Cell Populations.

Frontiers in immunology

Zimmermann MT, Kennedy RB, Grill DE, Oberg AL, Goergen KM, Ovsyannikova IG, Haralambieva IH, Poland GA.
PMID: 28484452
Front Immunol. 2017 Apr 21;8:445. doi: 10.3389/fimmu.2017.00445. eCollection 2017.

The development of a humoral immune response to influenza vaccines occurs on a multisystems level. Due to the orchestration required for robust immune responses when multiple genes and their regulatory components across multiple cell types are involved, we examined...

Showing 1 to 12 of 9224 entries